DNA

Persistent activation of the DNA damage response in the liver after MASLD reversal

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Persistent activation of the DNA damage response in the liver after MASLD reversal

Context and objectives Steatotic liver disease associated with metabolic dysfunction (MASLD) and its more advanced form, steatohepatitis associated with metabolic dysfunction, have become the most prevalent liver diseases worldwide. Currently, lifestyle modification is the most recommended management strategy for MASLD. However, it remains unclear which harmful signals persist in MASLD even after disease remission. Thus, … Read more

Selfish DNA is not only harmful, but plays a vital role in embryo development

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Selfish DNA is not only harmful, but plays a vital role in embryo development

Study finds that transposable elements, once thought to be parasitic, are crucial for early human development. Sinai Health researchers have shown that these genomic segments, called “selfish DNA”, in particular LINE-1, actively contribute to the proper formation of human embryos. Historically considered harmful, these elements represent approximately 20% of the human genome, while our functional … Read more