Persistent activation of the DNA damage response in the liver after MASLD reversal

Persistent activation of the DNA damage response in the liver after MASLD reversal

Context and objectives Steatotic liver disease associated with metabolic dysfunction (MASLD) and its more advanced form, steatohepatitis associated with metabolic dysfunction, have become the most prevalent liver diseases worldwide. Currently, lifestyle modification is the most recommended management strategy for MASLD. However, it remains unclear which harmful signals persist in MASLD even after disease remission. Thus, … Read more